Analgesic combination of oxycodone and celecoxib

作者: Ronald Burch , Paul Goldenheim , Richard Sackler

DOI:

关键词: Human patientCelecoxibDosage formOxycodoneAnalgesicAnalgesic effectMedicinePharmacology

摘要: Disclosed is a pharmaceutical composition, comprising two analgesic compounds and/or pharmaceutically acceptable salts thereof consisting of celecoxib at least one salt and oxycodone thereof, said in an amount sufficient to provide effect human patient. Also disclosed method effectively treating pain humans or other mammals, orally administering the patient oral dosage form

参考文章(121)
Walter Eversmeyer, Marcia Poland, Ralph E. DeLapp, Colleen P. Jensen, Safety experience with nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in osteoarthritis and rheumatoid arthritis. The American Journal of Medicine. ,vol. 95, ,(1993) , 10.1016/0002-9343(93)90391-2
S Boyce, C-C Chan, R Gordon, C-S Li, IW Rodger, JK Webb, NMJ Rupniak, RG Hill, L-745,337: A selective inhibitor of cyclooxygenase-2 elicits antinociception but not gastric ulceration in rats Neuropharmacology. ,vol. 33, pp. 1609- 1611 ,(1994) , 10.1016/0028-3908(94)90137-6
N. B. A. Hodsman, J. Burns, A. Blyth, G. N. C. Kenny, C. S. McArdle, H. Rotman, The morphine sparing effects of diclofenac sodium following abdominal surgery Anaesthesia. ,vol. 42, pp. 1005- 1008 ,(1987) , 10.1111/J.1365-2044.1987.TB05377.X
Ravi G. Kurumbail, Anna M. Stevens, James K. Gierse, Joseph J. McDonald, Roderick A. Stegeman, Jina Y. Pak, Daniel Gildehaus, Julie M. iyashiro, Thomas D. Penning, Karen Seibert, Peter C. Isakson, William C. Stallings, Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature. ,vol. 384, pp. 644- 648 ,(1996) , 10.1038/384644A0
Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw, Jeffery S. Carter, Paul W. Collins, Stephen Docter, Matthew J. Graneto, Len F. Lee, James W. Malecha, Julie M. Miyashiro, Roland S. Rogers, D. J. Rogier, Stella S. Yu, Gary D. Anderson, Earl G. Burton, J. Nita Cogburn, Susan A. Gregory, Carol M. Koboldt, William E. Perkins, Karen Seibert, Amy W. Veenhuizen, Yan Y. Zhang, Peter C. Isakson, Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). Journal of Medicinal Chemistry. ,vol. 40, pp. 1347- 1365 ,(1997) , 10.1021/JM960803Q
D. W. Gilroy, A. Tomlinson, D. A. Willoughby, Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation Inflammation Research. ,vol. 47, pp. 79- 85 ,(1998) , 10.1007/S000110050285
S. Sengupta, T. Velpandian, P. Sapra, P. Mathur, S.K. Gupta, Comparative analgesic efficacy of nimesulide and diclofenac gels after topical application on the skin. Skin Pharmacology and Applied Skin Physiology. ,vol. 11, pp. 273- 278 ,(1998) , 10.1159/000029837
Abraham Sunshine, Nancy Z. Olson, Edward O'Neill, Irma Ramos, Ralph Doyle, Analgesic Efficacy of a Hydrocodone with Ibuprofen Combination Compared with Ibuprofen Alone for the Treatment of Acute Postoperative Pain The Journal of Clinical Pharmacology. ,vol. 37, pp. 908- 915 ,(1997) , 10.1002/J.1552-4604.1997.TB04265.X