Inhibitors of the ceramide metabolic pathway as adjuncts to opiates for pain
作者： Daniela Salvemini
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摘要: A method for treating opiate induced tolerance or hyperalgesia in a subject is closed. More specifically, the provides reducing ceramide levels with an agent thereby antinociceptive/analgesic human non-human subject. The further allows improved pain management subjects suffering from chronic as well treatment disorders.
lens.org 参考文章(16)
Richard Deckelbaum, Tilla Worgall, Ceramide de novo synthesis-based therapeutic and prophylactic methods, and related articles of manufacture ,(2003)
Gino Toffano, Francesco Della Valle, Use of monosialoganglioside gm, to prevent the development of tolerance to the analgesic effect of morphine and related drugs ,(1991)
Kenneth R. Feingold, Peter M. Elias, Carl R. Thornfeldt, Walter M. Holleran, Method and compositions for disrupting the epithelial barrier function ,(1994)
Ke-Fei Shen, Stanley M. Crain, Methods for increasing analgesic potency and attenuating adverse excitatory effects of bimodally-acting opioid agonists by inhibiting GM1-ganglioside ,(2002)
John J. Farrar, Novel methods and compositions involving opioids and antagonists thereof ,(2000)
Sophia Kossida, Eiko Takao, Jeffrey Encinas, Regulation of human ceramide kinase ,(2003)
Ronald Burch, Paul Goldenheim, Richard Sackler, Analgesic combination of oxycodone and celecoxib ,(2001)
Paul D. Goldenheim, Richard S. Sackler, Ronald M. Burch, Synergistic analgesic combination of oxycodone and rofecoxib ,(1998)
Zaijie Wang, Method and composition for potentiating an opiate analgesic ,(2004)
Donald D. Price, Jianren Mao, David J. Mayer, John W. Lyle, Inhibiting the development of tolerance to and/or dependence on an addictive substance ,(1994)