Novel methods and compositions involving opioids and antagonists thereof
作者： John J. Farrar
DOI:
关键词: Constipation 、 μ-opioid receptor 、 Nausea 、 Antagonist 、 Medicine 、 Opioid 、 Vomiting 、 Pharmacology
摘要: Novel methods and compositions comprising opioids opioid antagonists. In preferred embodiments, the comprise peripheral mu antagonist compounds. The are particularly suitable for treating and/or preventing side effects associated with including, example, constipation, vomiting nausea. Figures 2A aand 2B graphical representations of studies on inhibition nausea employing according to an embodiment present invention,
lens.org 参考文章(143)
C. T. Frantzides, R. E. Condon, A. A. B. Ferraz, S. Carilli, F. Ezberci, V. E. Cowles, W. J. Schulte, Nonopioid analgesics shorten the duration of postoperative ileus. American Surgeon. ,vol. 61, pp. 1079- 1083 ,(1995)
Lawrence J. Brandt, Jonathan Resnick, David A. Greenwald, Delayed gastric emptying and postoperative ileus after nongastric abdominal surgery: part I. The American Journal of Gastroenterology. ,vol. 92, pp. 751- 762 ,(1997)
Schang Jc, Devroede G, Beneficial effects of naloxone in a patient with intestinal pseudoobstruction. The American Journal of Gastroenterology. ,vol. 80, pp. 407- ,(1985)
Milton Orchin, The vocabulary of organic chemistry Wiley. ,(1980)
Pierre J.M. Rivière, Xavier Pascaud, Eric Chevalier, Brigitte Le Gallou, Jean-Louis Junien, Fedotozine reverses ileus induced by surgery or peritonitis: Action at peripheral Κ-Opioid receptors Gastroenterology. ,vol. 104, pp. 724- 731 ,(1993) , 10.1016/0016-5085(93)91007-5
Robert Paul Charest, Haruko Mizoguchi, Sheri Ann Gilbert, Timothy Peter O'neill, Ronald Lee Smith, The use of loperamide and related compounds for treatment of respiratory disease symptoms ,(1992)
T Reisine, Opioid analgesics and antagonists Goodman & Gilman's The pharmacological basis of therapeutics. ,(1996)
Henry B. Abajian, John F. Noble, Joseph J. Hlavka, Tri-, tetra-, penta-, and polypeptides and their therapeutic use as an antidepressant agent ,(1995)
Ronald R. Tuttle, Ross Dixon, Maciej M. Smulkowski, Glucuronic acid derivatives of opioid antagonists ,(1988)
Gholam A. Peyman, Method of treatment of migraine ,(1998)