Lewis a antigen in transitional cell tumors of the urinary bladder.

摘要: The failure of A,B,H antigens as prognostic parameters in noninvasive bladder cancer blood group O individuals, who constitute 44% the population, encouraged evaluation closely related Lewis a antigen. Ninety-three tumors urinary were stained employing Tween 20 (Merck)-modified immunoperoxidase staining technique and serial dilution monoclonal anti-Lewis antibodies. On basis recent findings non-neoplastic ureter urothelium erythrocyte Lea+b-, Lea-b+, Lea-b- alterations tumors, except eight from quantified on scale 0 (normal) to 3 (total loss). Scores pathologic stage grade (P less than 0.01), and, Pa clinical course: recurrence rate 0.10), stroma invasive recurrence, and/or papillomatosis 0.05). Although further studies are needed current study points antigen determination an advantageous tool Lea-b+ Lea+b- who, together, 94% population.