Inverse Association between Dietary Intake of Selected Carotenoids and Vitamin C and Risk of Lung Cancer

摘要: While diets rich in fruit and vegetables appear to reduce lung cancer risk, the evidence for individual carotenoid vitamin intakes has been judged too limited reach firm conclusions. Data from a case-control study of (Montreal, Canada, 1996-2002) were used investigate role dietary β-carotene, α-carotene, β-cryptoxanthin, lutein/zeaxanthin, lycopene C risk. In-person interviews elicited information 1,105 incident cases 1,449 population controls. Usual frequency consumption 49 two years prior diagnosis/interview was collected. Odds ratios (OR) 95% confidence intervals (CI) between intake variables estimated using logistic or polytomous regression, adjusting potential confounding factors including detailed smoking history. ORs associated with upper vs. lower tertiles 0.66 (95% CI=0.51-0.84) 0.70 CI=0.55-0.90) 0.65 0.75 CI=0.59-0.95) 0.74 CI=0.58-0.96) C. suggestive protective effect found elevated β-cryptoxanthin male heavy smokers, female smokers. Selected antioxidants also risk moderate squamous cell carcinoma, adenocarcinoma small carcinoma. These results suggest that several common food sources may protect against cancer, even among