Terfestatins B and C, New p-Terphenyl Glycosides Produced by Streptomyces sp. RM-5–8
作者： Xiachang Wang , Anna R. Reynolds , Sherif I. Elshahawi , Khaled A. Shaaban , Larissa V. Ponomareva
DOI: 10.1021/ACS.ORGLETT.5B01203
关键词:
摘要: Terfestatins B (1) and C (2), new p-terphenyls bearing a novel unsaturated hexuronic acid (4-deoxy-α-l-threo-hex-4-enopyranuronate), unique β-d-glycosyl ester of 5-isoprenylindole-3-carboxylate (3) the same rare sugar, two hygromycin precursors, were characterized as metabolites coal mine fire isolate Streptomyces sp. RM-5–8. EtOH damage neuroprotection assays using rat hippocampal-derived primary cell cultures with 1, 2, 3 echoside (a terfestatin C-3′-β-d-glucuronide from RM-5–8) revealed 1 potently neuroprotective, highlighting potential application scaffold.
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