Diagnostic and prognostic epigenetic biomarkers in cancer.

摘要: Growing cancer incidence and mortality worldwide demands development of accurate biomarkers to perfect detection, diagnosis, prognostication monitoring. Urologic (prostate, bladder, kidney), lung, breast colorectal cancers are the most common despite major advances in their characterization, this has seldom translated into amenable for clinical practice. Epigenetic alterations innovative owing stability, frequency, reversibility accessibility body fluids, entailing great potential assay assist patient management. Several studies identified putative epigenetic biomarkers, some which have been commercialized. However, large multicenter validation required foster translation clinics. Herein we review promising diagnostic, prognostic predictive cancers.