RNA Interference in Cancer: Targeting the Anti-Apoptotic Protein c-FLIP for Drug Discovery

作者: Travis Day , Ahmad Safa

DOI: 10.2174/138955709788452748

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摘要: The silencing of genes by RNA interference (RNAi) has identified proteins involved in the resistance cancers to chemotherapeutic drugs. Resistance is associated with defects apoptotic signaling pathways. In this article, we examine using RNAi target anti-apoptotic protein cellular FLICE-like inhibitory (c-FLIP) for drug development.

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