Mast cell proteases.
作者： Gunnar Pejler , Magnus Åbrink , Maria Ringvall , Sara Wernersson
DOI: 10.1016/S0065-2776(07)95006-3
关键词:
摘要: Abstract Mast cells (MCs) are traditionally thought of as a nuisance for its host, example, by causing many the symptoms associated with allergic reactions. In addition, recent research has put focus on MCs displaying harmful effects during various autoimmune disorders. On other hand, can also be beneficial contributing to defense against insults such bacteria, parasites, and snake venom toxins. When MC is challenged an external stimulus, it may respond degranulation. this process, number powerful preformed inflammatory “mediators” released, including cytokines, histamine, serglycin proteoglycans, several MC‐specific proteases: chymases, tryptases, carboxypeptidase A. Although exact effector mechanism(s) which carry out their either or in vivo large parts unknown, reasonable assume that these mediators contribute profound ways. Among mediators, biological function proteases long time been relatively obscure. However, progress involving successful genetic targeting protease genes generated tools, will enable us unravel role both normal physiology well pathological settings. This chapter summarizes current knowledge biology proteases.
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