Obstetric cholestasis with elevated gamma glutamyl transpeptidase: Incidence, presentation and treatment

摘要: Background:  Obstetric cholestasis (OC) may cause severe pruritus in the mother and lead to fetal distress stillbirth. The etiology of OC is multifactorial, but includes inherited dysfunction bile canalicular transporters. One these, multidrug resistant protein 3 (MDR3), a phospholipid transporter, when dysfunctional associated with elevated levels gamma glutamyl transpeptidase (GGT). aim present study was assess incidence GGT. We compared natural history cholestatic pregnancy efficacy ursodeoxycholic acid (URSO) patients grouped according normal or raised GGT level. Methods:  Eighty-one were analyzed. diagnosed serum acids (SBA). Fifty-seven consenting volunteer (70%) treated URSO. Results:  Elevated at presentation found 21 (30%) significantly higher aspartate transaminase (AST), bilirubin (BIL) SBA. presented approximately same gestation week both groups patients. In not URSO, liver function tests (LFT) showed no significant change from time diagnosis delivery. Patients responded URSO improvement their AST alanine aminotransferase (ALT) levels, SBA fell only group. Conclusions:  An occurs less than one-third UK and, present, greater impairment LFT, difference gestational age onset. Treatment appears be safe improves LFT OC, exception high group.