Coronary flow velocity reserve is impaired in hypertensive patients with hyperhomocysteinemia.

摘要: Hyperhomocysteinemia (HHcy) is an independent risk factor for coronary artery disease. Chronic HHcy induces endothelial injury, and homocysteine (Hcy) inhibits insulin sensitivity by inducing endoplasmic reticulum stress in adipose tissue. However, the combined effects of chronic hypertension on function have still remained unclear. Fifty-one patients with essential (HT) were recruited, divided into nHT group (without HHcy) H-type HT (with HHcy). Forty healthy subjects enrolled as controls. We assessed flow velocity reserve (CFVR). Hcy levels significantly higher (15.60±6.58 vs 13.08±4.13 μmol l−1, P<0.05), whereas CFVR values lower than control (2.88±0.70 3.23±0.54, P<0.05). negatively correlated value (r=−0.578, P<0.01, 95% confidence interval −0.085 to −0.046). The homeostasis model assessment-insulin resistance (3.92±2.16 2.72±1.50, P<0.05) , (2.31±0.31 3.25±0.62, P<0.01). Coronary may be impaired hypertensive HHcy, induced contribute this damage.