Endothelial dysfunction and inflammation in different stages of essential hypertension.

摘要: The objective of this study was to assess the various factors affecting endothelial function in essential hypertensives and establish a relation between them regression model. Also, micro-inflammatory state that is known exist hypertension evaluated. Sixty newly detected patients not on any prior treatment classified into Stage-1 or Stage-2 according JNC-VII criteria were recruited study. After detailed history physical examination, investigations including blood urea, serum creatinine, sugar (F), S. lipid profile urine for albumin, sediments, X-ray chest, ECG fundus examination carried out. Urine microalbuminuria, Hs-CRP brachial artery reactivity tested as markers dysfunction inflammation. CRP levels, taken marker inflammation hypertension, significantly elevated majority subjects. Endothelial more quantified compared with (P < 0.01). levels consistently found be both stages our study, an insignificant difference two groups. A significant association noted stage triglycerides, CRP, LDL cholesterol age, emerging most powerful predictor variable 0.0001) followed closely by microalbuminuria multiple analysis present reinforces view part inflammatory disorder. important component severity being determined LDL-cholesterol, age independently. undesirable response can cost-effectively prevented at targeting potentially modifiable risk elucidated