Enantioseparation of α‐Hydroxyallylphosphonates and Phosphonoallylic Carbonate Derivatives on Chiral Stationary Phases Using Sequential UV, Polarimetric, and Refractive Index Detection
作者： Bruce C. Hamper , Michael P. Mannino , Melissa E. Mueller , Liam T. Harrison , Christopher D. Spilling
DOI: 10.1002/CHIR.22627
关键词:
摘要: Chromatographic separation of the enantiomers parent compounds dimethyl α-hydroxyallyl phosphonate and 1-(dimethoxyphosphoryl) allyl methyl carbonate was demonstrated by high-performance liquid chromatography (HPLC) using Chiralpak AS-H ad-H chiral stationary phases (CSP), respectively, a combination UV, polarimetric, refractive index detectors. A comparison made efficiency elution order enantiomeric phosphonates their derivatives on commercially available polysaccharide AS, ad, OD, IC-3, Whelk-O 1 CSPs. In general, were resolved CSP, whereas preferentially CSP. The impact aryl substitution resolution analytes evaluated. Thermodynamic parameters determined for enantioselective adsorption hydroxyphosphonates CSP enthalpic control enantiomers. Chirality 28:656-662, 2016. © 2016 Wiley Periodicals, Inc.
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