Phosphatidic Acid Synthesis in Bacteria

摘要: Membrane phospholipid synthesis is a vital facet of bacterial physiology. Although the spectrum headgroup structures produced by bacteria large, key precursor to all these molecules phosphatidic acid (PtdOH). Glycerol-3-phosphate derived from glycolysis via glycerol-phosphate synthase universal source for glycerol backbone PtdOH. There are two distinct families enzymes responsible acylation 1-position glycerol-3-phosphate. The PlsB acyltransferase was discovered in Escherichia coli, and homologs present many eukaryotes. This protein family primarily uses acyl-acyl carrier (ACP) endproducts fatty as acyl donors, but may also use acyl-CoA exogenous acids. second family, PlsY, more widely distributed utilizes unique donor, acyl-phosphate, which acyl-ACP enzyme PlsX. 2-position carried out members PlsC family. All PlsCs although γ-proteobacteria acyl-CoA. Phospholipid headgroups precursors biosynthesis other membrane-associated diacylglycerol product reactions converted PtdOH one lipid kinases. central importance de novo recycling pathways cell physiology suggest that suitable targets development antibacterial therapeutics Gram-positive pathogens. article part Special Issue entitled Phospholipids Metabolism.