LF16-0687 A Novel Non-Peptide Bradykinin B2 Receptor Antagonist Reduces Vasogenic Brain Edema from a Focal Lesion in Rats
作者： J. Schulz , Nikolaus Plesnila , J. Eriskat , M. Stoffel , D. Pruneau
DOI: 10.1007/978-3-7091-6346-7_28
关键词:
摘要: Head injury world wide is still the most frequent cause of morbidity and mortality among population under 45 years. Approximately 50% patients dying from severe head have a therapy refractory intracranial pressure rise (Baethmann 1998). Traumatic brain edema, e.g. resulting disruption blood-brain barrier viewed as an important factor increased pressure. Bradykinin, active peptide kallikrein-kinin system considered to enhance edema formation which attributed its permeabilizing effect on dilation arterial blood vessels in mediated by B2-receptors facilitating extravasation.
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