Asymmetric segregation of Numb in retinal development and the influence of the pigmented epithelium.
作者： Michel Cayouette , Alan V. Whitmore , Glen Jeffery , Martin Raff
DOI: 10.1523/JNEUROSCI.21-15-05643.2001
关键词:
摘要: Asymmetric segregation of cell-fate determinants during cytokinesis plays an important part in controlling choice invertebrates. During Drosophila neurogenesis, for example, asymmetric the Numb protein, which inhibits Notch signaling, is necessary two daughter cells a division to have different fates. In vertebrates, role uncertain, and way process might be regulated unknown. We studied orientation cell divisions distribution developing rat retina. show that, whereas most retinal neuroepithelial divide with their mitotic spindles oriented parallel plane neuroepithelium, substantial minority divides perpendicularly. The proportion these vertically dividing changes development, peaking around day birth. appears inherited only by apical when vertically. Similarly, dissociated cultures, some asymmetrically distribute one cells, suggesting that can retain polarity vitro. Using explant we find pigment epithelium apparently promotes vertical neural To our knowledge, this first evidence may contribute diversification mammalian retina controls influencing adjacent
sci-hub.se 参考文章(46)
Markus Schober, Matthias Schaefer, Juergen A. Knoblich, Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature. ,vol. 402, pp. 548- 551 ,(1999) , 10.1038/990135
Gérard Joberty, Clark Petersen, Lin Gao, Ian G. Macara, The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nature Cell Biology. ,vol. 2, pp. 531- 539 ,(2000) , 10.1038/35019573
Andreas Wodarz, Andreas Ramrath, Ute Kuchinke, Elisabeth Knust, Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts. Nature. ,vol. 402, pp. 544- 547 ,(1999) , 10.1038/990128
Kenneth J. Kemphues, Tak-June Hung, PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos Development. ,vol. 126, pp. 127- 135 ,(1999) , 10.1242/DEV.126.1.127
Jürgen A. Knoblich, Jan, Yuh Nung Jan, Asymmetric segregation of Numb and Prospero during cell division Nature. ,vol. 377, pp. 624- 627 ,(1995) , 10.1038/377624A0
Bingwei Lu, Fabrice Roegiers, Lily Y. Jan, Yuh Nung Jan, Adherens junctions inhibit asymmetric division in the Drosophila epithelium Nature. ,vol. 409, pp. 522- 525 ,(2001) , 10.1038/35054077
Nicholas Gaiano, Jeffrey S. Nye, Gord Fishell, Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain Neuron. ,vol. 26, pp. 395- 404 ,(2000) , 10.1016/S0896-6273(00)81172-1
Kenneth J. Kemphues, James R. Priess, Diane G. Morton, Niansheng Cheng, Identification of genes required for cytoplasmic localization in early C. elegans embryos Cell. ,vol. 52, pp. 311- 320 ,(1988) , 10.1016/S0092-8674(88)80024-2
Eric P Spana, Chris Q Doe, Numb Antagonizes Notch Signaling to Specify Sibling Neuron Cell Fates Neuron. ,vol. 17, pp. 21- 26 ,(1996) , 10.1016/S0896-6273(00)80277-9
Constance L Cepko, The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates. Current Opinion in Neurobiology. ,vol. 9, pp. 37- 46 ,(1999) , 10.1016/S0959-4388(99)80005-1