Pyrazinamide Is Active against Mycobacterium tuberculosis Cultures at Neutral pH and Low Temperature
作者： Alice L. den Hertog , Sandra Menting , Richard Pfeltz , Matthew Warns , Salman H. Siddiqi
DOI: 10.1128/AAC.00654-16
关键词:
摘要: For the past decades, an acidic pH has been used to render Mycobacterium tuberculosis susceptible pyrazinamide for in vitro testing. Here, we show that at standard breakpoint concentration and reduced culture temperatures, (PZA) is active against (TB) neutral pH. This finding should help unravel mechanism of action PZA allow drug susceptibility testing (DST) methods be optimized.
narcis.nl参考文章(29)
Ralph Tompsett, Walsh McDermott, Activation of pyrazinamide and nicotinamide in acidic environments in vitro. American review of tuberculosis. ,vol. 70, pp. 748- 754 ,(1954) , 10.1164/ART.1954.70.4.748
Ying Zhang, D. Mitchison, The curious characteristics of pyrazinamide: a review. International Journal of Tuberculosis and Lung Disease. ,vol. 7, pp. 6- 21 ,(2003)
Holger Schünemann, Dennis Falzon, Ernesto Jaramillo, The 2011 update of the World Health Organization guidelines for the programmatic management of drug-resistant tuberculosis European Respiratory Journal. ,vol. 38, pp. 393- ,(2011)
Jacob J. Baker, Benjamin K. Johnson, Robert B. Abramovitch, Slow growth ofMycobacterium tuberculosisat acidic pH is regulated byphoPRand host-associated carbon sources Molecular Microbiology. ,vol. 94, pp. 56- 69 ,(2014) , 10.1111/MMI.12688
YING ZHANG, ZHONGHE SUN, SALLIE PERMAR, Conditions that may affect the results of susceptibility testing of Mycobacterium tuberculosis to pyrazinamide Journal of Medical Microbiology. ,vol. 51, pp. 42- 49 ,(2002) , 10.1099/0022-1317-51-1-42
Mark A. Fisher, Bonnie B. Plikaytis, Thomas M. Shinnick, Microarray Analysis of the Mycobacterium tuberculosis Transcriptional Response to the Acidic Conditions Found in Phagosomes Journal of Bacteriology. ,vol. 184, pp. 4025- 4032 ,(2002) , 10.1128/JB.184.14.4025-4032.2002
W. Shi, X. Zhang, X. Jiang, H. Yuan, J. S. Lee, C. E. Barry, H. Wang, W. Zhang, Y. Zhang, Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis. Science. ,vol. 333, pp. 1630- 1632 ,(2011) , 10.1126/SCIENCE.1208813
Derrick R. Seiner, Subray S. Hegde, John S. Blanchard, Kinetics and Inhibition of Nicotinamidase from Mycobacterium tuberculosis Biochemistry. ,vol. 49, pp. 9613- 9619 ,(2010) , 10.1021/BI1011157
Alice L den Hertog, Sandra Menting, Ernst T Smienk, Jim Werngren, Sven Hoffner, Richard M Anthony, Evaluation of a microcolony growth monitoring method for the rapid determination of ethambutol resistance in Mycobacterium tuberculosis BMC Infectious Diseases. ,vol. 14, pp. 380- 380 ,(2014) , 10.1186/1471-2334-14-380
Nicola Casali, Vladyslav Nikolayevskyy, Yanina Balabanova, Simon R Harris, Olga Ignatyeva, Irina Kontsevaya, Jukka Corander, Josephine Bryant, Julian Parkhill, Sergey Nejentsev, Rolf D Horstmann, Timothy Brown, Francis Drobniewski, Evolution and transmission of drug-resistant tuberculosis in a Russian population Nature Genetics. ,vol. 46, pp. 279- 286 ,(2014) , 10.1038/NG.2878