Peripheral adiponectin levels in anxiety, mood, trauma- and stressor-related disorders: A systematic review and meta-analysis.

摘要: Abstract Background Anxiety, mood, trauma- and stressor-related disorders confer increased risk for metabolic disease. Adiponectin, a cytokine released by adipose tissue is associated with these obesity via inflammatory processes. Available data describing associations mental remain limited conflicted. Methods A systematic search was conducted English, peer-reviewed articles from inception until February 2019 that assessed serum or plasma adiponectin levels in adults an anxiety, mood trauma-related disorder. Diagnoses were determined psychiatric interview, based on DSM-IV, DSM-5 ICD-10 criteria. Analyses performed using STATA 15 Standardized mean difference (SMD) 95% confidence interval applied to pool the effect size of meta-analysis studies. Results In total 65 eligible studies included review 30 this meta-analysis. 19,178 participants (11,262 females 7916 males), comprising healthy disorders, included. Overall results indicated inverse association between examined disorders. Specifically, patients anxiety disorder (SMD  = −1.18 µg/mL, CI, −2.34; −0.01, p  = 0.047); trauma (SMD  =  −0.34 µg/mL, −0.52; −0.17, p  = 0.0000) bipolar (SMD  =  −0.638 µg/mL, −1.16, −0.12, p  = 0.017) had significant lower compared adults. Limitations Heterogeneity, potential publication bias, lack control important confounders limitations. Conclusion Peripheral appear be inversely stressor related may promising biomarker diagnosis disease monitoring.