Complementary stereocontrolled approaches to 2-pyrrolidinones bearing a vicinal amino diol subunit with three continuous chiral centers: A formal asymmetric synthesis of (-)-detoxinine
作者： Xiang Zhou , Wen-Jun Liu , Jian-Liang Ye , Pei-Qiang Huang
DOI: 10.1021/JO7018784
关键词:
摘要: We report herein two stereocomplementary approaches to erythro/trans and threo/cis vicinal amino diol subunits containing 2-pyrrolidinones (9 10) starting from the known enamides 7, easily available malimides. The first approach consists of an epoxidation-reductive dehydroxylation procedure, second one is based on hydroboration-oxidation reactions. Using method, a formal asymmetric synthesis (-)-detoxinine was achieved.
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