Synthesis of 3-hydroxy and 3-amino 2-substituted N-heterocycles via enamine oxidation and aziridination
作者： Mihiro Sunose , Kirsty M. Anderson , A. Guy Orpen , Timothy Gallagher , Simon J.F. Macdonald
DOI: 10.1016/S0040-4039(98)01915-7
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摘要: Reaction of the N -sulfonyl heterocyclic enamines ( 1a/b ) under asymmetric epoxidation and dihydroxylation reaction conditions leads to 2,3-dihydroxypyrrolidines piperidines, 2a 2b ). Only diols are observed aminohydroxylation conditions, but Mn-mediated aziridination 1a provides a route 3-amino-2-methoxypyrrolidine derivatives 6 7
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