Novel method for the treatment of systemic lupus erythematosus
作者： George Tsokos , Yuang-Taung Juang
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摘要: A method for the treatment of systemic lupus erythematosus (SLE) by administering antisense cAMP response element modulator (antisense CREM) to patients with erythematosus. The CREM increases production Interleukin-2 (IL-2) which is decreased in SLE patients. Additionally, this invention relates taking freshly isolated T cells and transfecting them TCR ζ chain construct a eukaryotic expression vector, at high efficiency recently developed nucleoporation technique restoration TCR/CD3-mediated signaling transfected cells. Reconstitution deficient can reverse abnormalities as well defective IL-2
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