Pathomechanisms of discogenic low back pain in humans and animal models

摘要: Abstract Background context Although explored in humans and animal models, the pathomechanisms of discogenic low back pain (LBP) remain unknown. Purpose The aim this study was to review literature about LBP. Methods Animal models specimens from degenerated human intervertebral discs (IVDs) have provided clues Painful are characterized by a confluence innervation, inflammation, mechanical hypermobility. These three possible mechanisms discussed review. Results revealed sensory innervation lumbar IVDs nerve ingrowth into inner layer IVDs. Cytokines such as tumor necrosis factor-α interleukins induce ingrowth. Nerve growth factor has also been recently identified an inducer Finally, disc degeneration induces several collagenases; their action results hypermobility pain. Conclusions To treat LBP, it is important prevent sensitization fibers innervating IVD, suppress pathogenic increases cytokines, decrease