Swim exercise in C. elegans extends neuromuscular and intestinal healthspan, enhances learning ability, and protects against neurodegeneration

摘要: Abstract Exercise can protect against cardiovascular disease, neurodegenerative diabetes, cancer, and age-associated declines in muscle, immune, cognitive function. In fact, regular physical exercise is the most powerful intervention known to enhance robustness of health aging. Still, molecular cellular mechanisms that mediate system-wide benefits remain poorly understood, especially as applies “off target” tissues do not participate directly training activity. Elaborating whole-animal therefore considerable importance human health. The development protocols for short-lived genetic models holds great potential deciphering fundamental trans-tissue signaling during entire aging process. Here, we report on optimization a long-term swim protocol C. elegans demonstrate its diverse tissues, even if occurs only restricted phase early adulthood. We found multiple daily sessions are essential adaptation elegans, leading body wall muscle improvements structural gene expression, locomotory performance, mitochondrial morphology. Swim enhances parameters such respiration mid-life survival increases functional healthspan pharynx intestine. Importantly, show also nervous system health: learning ability adult animals protects neurodegeneration tauopathy, Alzheimer’s Huntington’s disease. An important point adulthood induces long-lasting systemic several cases still detectable well into mid-life. Overall, our data reveal broad impact promoting extended underscore potency experience influence (even after cessation exercise), establish foundation exploiting advantages this model dissect exercise-dependent circuitry confers or diseased adults.