Short-term toxicity study of di-(2-ethylhexyl) phthalate in rats.

摘要: Abstract Groups of 15 male and female rats were given diet containing 0 (control), 0·2, 1·0 or 2·0% di-(2-ethylhexyl) phthalate (DEHP) for 17 wk. At the two higher treatment levels there was a reduced rate body-weight gain food intake. A paired-feeding study showed that intake did not account fully growth rate. There decreased packed cell volume in both sexes 1 2% DEHP, these haemoglobin concentration also reduced. However, no decrease total erythrocyte count. Renal concentrating diluting ability females receiving DEHP. differences between treated control results serum analyses. With exception liver weights, which higher, absolute weights most organs DEHP lower than those controls, while relative values greater. This pattern considered to be related body at autopsy. levels, testis weight markedly histopathological examination revealed severe seminiferous tubular atrophy cessation spermatogenesis. The fed 0·2% reduced, but histologically evidence wk 17, castration cells observed pituitary all incidence being dose-related. other changes attributable treatment. In view testicular increase it possible establish no-untoward-effect level this study.