Efflux-mediated multiresistance in Gram-negative bacteria

摘要: Multiresistance in Gram-negative pathogens, particularly Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Acinetobacter spp. and the Enterobacteriaceae, is a significant problem medicine today. While multiple mechanisms often contribute to multiresistance, broadly distributed family of three-component multidrug efflux systems an increasingly recognised determinant both intrinsic acquired multiresistance these organisms. Homologues are also readily identifiable genome sequences wide range organisms, pathogens non-pathogens alike, where they probably promote efflux-mediated resistance antimicrobials. Significantly, accommodate biocides, raising spectre biocide-mediated selection pathogens. there some debate as natural function systems, only which inducible by their antimicrobial substrates, contribution variety nonetheless makes them reasonable targets for therapeutic intervention. Indeed, given incredible chemical diversity substrates accommodated it likely that many novel or yet be discovered antimicrobials will themselves and, such, inhibitors may become important component therapy.