Imaging considerations of central nervous system manifestations in pediatric patients with neurofibromatosis type 1

摘要: CT and MRI were used in a prospective study of the central nervous system (CNS) manifestations 41 consecutive children with neurofibromatosis type 1 (NF-1). Gadolinium-DTPA was 15 patients. more effective than delimiting extension optic pathway glioma evaluating associated cerebral malformations. visualized lesions generally undetected by CT, form iso- or hyperintense foci respect to cortex T2-weighted sequences. Well-delimited high signal intensity observed globus pallidus (22 cases), internal capsule (6 corpus callosum (2 anterior commissure (1 case) semioval center cases). Poorly defined hyper- isointense areas also affecting cerebellar white matter (21 cases) brain stem (17 None these showed enhancement, no clinical significance. has displaced initial diagnosis patients NF-1. Periodic annual controls are only justified changes evaluate progression stabilization lesions.