Neuroendocrine Control of Growth Hormone Secretion
作者： Eugenio E. Müller , Vittorio Locatelli , Daniela Cocchi
DOI: 10.1152/PHYSREV.1999.79.2.511
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摘要: The secretion of growth hormone (GH) is regulated through a complex neuroendocrine control system, especially by the functional interplay two hypothalamic hypophysiotropic hormones, GH-releasing (GHRH) and somatostatin (SS), exerting stimulatory inhibitory influences, respectively, on somatotrope. neurohormones are subject to modulation host neurotransmitters, noradrenergic cholinergic ones other neuropeptides, final mediators metabolic, endocrine, neural, immune influences for GH. Since identification GHRH peptide, recombinant DNA procedures have been used characterize corresponding cDNA clone receptor isoforms in rodent human pituitaries. Parallel research into effects SS its analogs endocrine exocrine secretions, investigations their mechanism action led discovery five separate genes encoding f...
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