Carbamazepine-provoked hepatotoxicity and possible aetiopathological role of glutathione in the events: Retrospective review of old data and call for new investigation

摘要: The antiepileptic drug (AED) carbamazepine is widely used in the treatment of different kinds seizures as well affective and behavioural disorders. This paper presents an epidemiological study carbamazepine-induced hepatic injuries death, describes possible mechanisms its toxicity. A retrospective analysis clinical data revealed that likelihood death was comparatively higher children, particularly when they were receiving medication with multiple AEDs, whereas reversible more likely to be seen elderly patients. As suggested this paper, development hepatotoxicity rare, unpredictable present state knowledge, but it somehow related disturbance glutathione metabolism, although regard are imperfect. There appear two types carbamazepine-initiated idiosyncratic liver injury, hypersensitivity toxin-induced. It feasible both due accumulation toxic metabolite(s), arene oxides may probably considered damaging derivatives metabolism. Despite lack clear-cut underlying experimental findings those patients whom inherited weakness eliminating capacity present, conditions deteriorate balance, increase possibility emergence events during therapy. Finally, some recommendations for therapy presented.