Redefining the origin and evolution of ovarian cancer: a hormonal connection.

摘要: Ovarian cancer has the highest mortality of all female reproductive cancers. Late diagnosis, tumour heterogeneity and development chemoresistance contribute to this statistic work against patient survival. Current studies have revealed novel concepts that impact our view on how ovarian develops. The greatest is understanding that, as a disease, multiple cellular origins these malignant precursors are mostly derived from outside ovaries. In review, we propose new concept step-wise developmental process may underwrite tumorigenesis progression: (1) migration/recruitment ovaries; (2) seeding establishment in (3) induction dormant stage; (4) expansion tumor progression. We will discuss relationship each step with changing function milieu during age subsequent occurrence menopause. realization progression occurs distinct steps critical for search adequate markers early detection offer personalized strategies prevention therapy.