The molecular assessment of SARS-CoV-2 Nucleocapsid Phosphoprotein variants among Indian isolates
DOI: 10.1016/J.HELIYON.2021.E06167
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摘要: Abstract Coronavirus disease- 2019 (COVID-19) has rapidly become a major threat to humans due its high infection rate and deaths caused worldwide. This disease is by an RNA virus, Severe Acquired Respiratory Syndrome –Corona Virus-2 (SARS-CoV-2). class of viruses have mutation than DNA that enables them adapt also evade host immune system. Here, we compared the first known Nucleocapsid Phosphoprotein (N protein) sequence SARS-CoV-2 from China with sequences Indian COVID-19 patients understand, if this virus mutating, as it spreading new locations. Our data revealed twenty mutations present among isolates. Out these, at six positions led changes in secondary structure N protein. Further, show these are primarily destabilising protein structure. The candidate identified study may help speed up understanding variations occurring SARS-CoV-2.
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