Novel colloidal carriers for psoriasis: Current issues, mechanistic insight and novel delivery approaches
作者： Madhulika Pradhan , Deependra Singh , Manju Rawat Singh
DOI: 10.1016/J.JCONREL.2013.05.020
关键词:
摘要: Psoriasis is an autoimmune disorder of the skin with relapsing episodes inflammation and hyperkeratosis. Numerous approaches have been explored to treat this dreadful disease using different antipsoriatic drugs modes action routes administration. But, till date there no cure for psoriasis due lack ideal carrier safe effective delivery drugs. Constant progression in development newer formulations utilizing colloidal drug systems has led treatment psoriasis. Colloidal carriers include vesicular particulate like liposome, transferosome, niosomes, ethosomes, solid lipid nanoparticles, microspheres, micelles, dendrimers etc. gained unique position as cargoes. Present review attempt contemplate on terms pathogenesis, role cytokines, major hindrances treatment, currently available options pertaining mode action, pharmacokinetics, marketed products, side effects individual recent developments various through novel carriers.
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