Stimulation of hepatic cytochrome b5-mediated lipid desaturation by renal microsomes
作者： Dominick L. Cinti , Mark R. Montgometry
DOI: 10.1016/0024-3205(76)90198-3
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摘要: Abstract Although microsomes prepared from rat kidney cortex contained significant concentrations of both NADH cytochrome b 5 reductase and , they did not catalyze -dependent Δ 9 oxidative lipid desaturation. However, incubation in the presence control liver resulted a two-fold increase fatty acid desaturase activity over that seen with alone. Addition to animals maintained on fat free diet an increased which was twice preparation. Kidney alone P-450-dependent N-demethylation aminopyrine, contrast desaturate, no demethylase observed when were added microsomes.
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