Improvement of Hyperglycemia and Sexual Dysfunction in Diabetic Female Rats by an Artificial Endocrine Pancreas Developed from Mouse β Cells
作者： Haruo HASHIMOTO , Naoki MORITANI , Misao TERADA , Pudcharaporn KROMKHUN , Wirasak FUNGFUAUG
关键词:
摘要: We investigated the effects of a bioartificial endocrine pancreas (Bio-AEP) produced by mouse beta cells on sexual dysfunction streptozotocin (STZ)-induced diabetic female rats. Female rats were administered STZ (60 mg/kg BW, i.v.) at age 10 weeks and transplanted with Bio-AEP including 14 (STZ+Bio-AEP group). Lordosis proceptive behavior observed. The results showed that after transplant blood glucose recovered from 380-450 mg/dl induced to 140-230 suppressed lordosis also recovered. These suggest it is possible reverse continuous administration insulin.
sci-hub.se 参考文章(4)
Akihiko Yonezawa, Manabu Ebiko, Masaru Yoshizumi, Shin-nosuke Ise, Chizuko Watanabe, Hirokazu Mizoguchi, Masahiro Iwasaki, Yukio Kimura, Shinobu Sakurada, Effects of insulin replacement on ejaculatory dysfunction in streptozotocin-induced diabetic rats International Journal of Urology. ,vol. 16, pp. 208- 211 ,(2009) , 10.1111/J.1442-2042.2008.02214.X
Hisako Ohgawara, Jun-Ichi Miyazaki, Yoshihiko Nakagawa, Sumihiko Sato, Sachiyo Karibe, Toshihiro Akaike, Xenoimplantation using a diffusion chamber with a B-cell line (MIN6) as a bioartificial endocrine pancreas (BIO-AEP) Cell Transplantation. ,vol. 5, ,(1996) , 10.1016/0963-6897(96)00044-9
Kazuya EDAMURA, Koko NASU, Yukiko IWAMI, Ryohei NISHIMURA, Hiroyuki OGAWA, Nobuo SASAKI, Hisako OHGAWARA, Prevalence of porcine endogenous retrovirus in domestic pigs in Japan and its potential infection in dogs xenotransplanted with porcine pancreatic islet cells. Journal of Veterinary Medical Science. ,vol. 66, pp. 129- 135 ,(2004) , 10.1292/JVMS.66.129
R. W. Steger, S. G. Kienast, Effect of continuous versus delayed insulin replacement on sex behavior and neuroendocrine function in diabetic male rats. Diabetes. ,vol. 39, pp. 942- 948 ,(1990) , 10.2337/DIAB.39.8.942