Loss of p16INK4A expression in low-grade ovarian serous carcinomas.
作者： Peter W. Schlosshauer , Liane Deligdisch , Frédérique Penault-Llorca , Delaram Fatemi , Rui Qiao
DOI: 10.1097/PGP.0B013E3181ED89B3
关键词:
摘要: According to a tumor progression model, low-grade ovarian serous carcinomas may evolve from borderline tumors or micropapillary tumors. We sought investigate the role of and associations between BRAF mutational status, extracellular signal regulated kinase activation, p16(INK4A) expression in various types analyzed 29 typical tumors, 8 4 invasive carcinomas, 24 high-grade for status at codon 600; addition, levels downstream signaling protein suppressor were assessed by immunohistochemistry. There was decline with almost complete loss carcinomas. High-grade had variable pattern. found T1799A mutation 12 (41%) 1 (12.5%). No mutations (0%). Among cases tended have stronger compared wild-type BRAF. other correlations identified proteins. Loss be pathogenetic factor The divergent molecular profiles support theory that are unrelated
utsystem.edu参考文章(31)
W. Remmele, K.-H. Schicketanz, Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer: Computer-assisted image analysis (QIC score) vs. subjective grading (IRS) Pathology Research and Practice. ,vol. 189, pp. 862- 866 ,(1993) , 10.1016/S0344-0338(11)81095-2
Dorothy C. Bennett, How to make a melanoma: what do we know of the primary clonal events? Pigment Cell & Melanoma Research. ,vol. 21, pp. 27- 38 ,(2007) , 10.1111/J.1755-148X.2007.00433.X
S. E. Hilary Russell, W. Glenn McCluggage, A multistep model for ovarian tumorigenesis: the value of mutation analysis in the KRAS and BRAF genes. The Journal of Pathology. ,vol. 203, pp. 617- 619 ,(2004) , 10.1002/PATH.1563
Yanhua Zhao, Yan Zhang, Zhen Yang, Albert Li, Jianli Dong, Simultaneous knockdown of BRAF and expression of INK4A in melanoma cells leads to potent growth inhibition and apoptosis Biochemical and Biophysical Research Communications. ,vol. 370, pp. 509- 513 ,(2008) , 10.1016/J.BBRC.2008.03.148
C J O'Neill, H A McBride, L E Connolly, M T Deavers, A Malpica, W G McCluggage, High-grade ovarian serous carcinoma exhibits significantly higher p16 expression than low-grade serous carcinoma and serous borderline tumour Histopathology. ,vol. 50, pp. 773- 779 ,(2007) , 10.1111/J.1365-2559.2007.02682.X
M Ruhul Quddus, Lanita B Rashid, Katrine Hansen, C James Sung, W Dwayne Lawrence, High-grade serous carcinoma arising in a low-grade serous carcinoma and micropapillary serous borderline tumour of the ovary in a 23-year-old woman. Histopathology. ,vol. 54, pp. 771- 773 ,(2009) , 10.1111/J.1365-2559.2009.03283.X
Yanping Zhang, Yue Xiong, Wendell G Yarbrough, ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell. ,vol. 92, pp. 725- 734 ,(1998) , 10.1016/S0092-8674(00)81401-4
Jane E Armes, Rohan Lourie, Melanie de Silva, Georgia Stamaratis, Alison Boyd, Beena Kumar, Gareth Price, Simon Hyde, David Allen, Peter Grant, Deon J Venter, Abnormalities of the RB1 pathway in ovarian serous papillary carcinoma as determined by overexpression of the p16(INK4A) protein. International Journal of Gynecological Pathology. ,vol. 24, pp. 363- 368 ,(2005) , 10.1097/01.PGP.0000172083.94934.1E
Chung-Liang Ho, Robert J. Kurman, Reiko Dehari, Tian-Li Wang, Ie-Ming Shih, Mutations of BRAF and KRAS Precede the Development of Ovarian Serous Borderline Tumors Cancer Research. ,vol. 64, pp. 6915- 6918 ,(2004) , 10.1158/0008-5472.CAN-04-2067
Reiko Dehari, Robert J. Kurman, Sanjay Logani, Ie-Ming Shih, The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis. The American Journal of Surgical Pathology. ,vol. 31, pp. 1007- 1012 ,(2007) , 10.1097/PAS.0B013E31802CBBE9