Kinetics of the viral cycle influence pharmacodynamics of antiretroviral therapy.
作者： Ahmad R Sedaghat , Claus O Wilke
关键词:
摘要: Background More and more antiretroviral therapies are being developed for treatment of HIV infection. The in-vivo efficacy these drugs is commonly predicted based on in-vitro measures antiviral effect. One primary measure the IC50, amount drug required 50% inhibition viral replication. We have previously shown that life-cycle kinetics impact clinically observed dynamics. Here we present a mathematical model how they affect pharmacodynamics drugs.
biomedcentral.com
springer.com
paperity.org参考文章(34)
Robert F. Siliciano, Robert F. Siliciano, Claus O. Wilke, Ahmad R. Sedaghat, Constraints on the dominant mechanism for HIV viral dynamics in patients on raltegravir. Antiviral Therapy. ,vol. 14, pp. 263- 271 ,(2009)
S S Carroll, M Stahlhut, J Geib, D B Olsen, Inhibition of HIV-1 reverse transcriptase by a quinazolinone and comparison with inhibition by pyridinones. Differences in the rates of inhibitor binding and in synergistic inhibition with nucleoside analogs Journal of Biological Chemistry. ,vol. 269, pp. 32351- 32357 ,(1994) , 10.1016/S0021-9258(18)31642-9
John W. Mellors, John E. McKinnon, Susan Swindells, Simplification strategies to reduce antiretroviral drug exposure: progress and prospects. Antiviral Therapy. ,vol. 14, pp. 1- 12 ,(2009)
J Abbotts, M Jaju, S H Wilson, Thermodynamics of A:G Mismatch Poly(dG) Synthesis by Human Immunodeficiency Virus 1 Reverse Transcriptase* Journal of Biological Chemistry. ,vol. 266, pp. 3937- 3943 ,(1991) , 10.1016/S0021-9258(19)67883-X
E. Fumero, D. Podzamczer, New patterns of HIV-1 resistance during HAART Clinical Microbiology and Infection. ,vol. 9, pp. 1077- 1084 ,(2003) , 10.1046/J.1469-0691.2003.00730.X
M Perez‐Olmeda, J Garcia‐Perez, E Mateos, S Spijkers, MC Ayerbe, A Carcas, J Alcami, None, In vitro analysis of synergism and antagonism of different nucleoside/nucleotide analogue combinations on the inhibition of human immunodeficiency virus type 1 replication. Journal of Medical Virology. ,vol. 81, pp. 211- 216 ,(2009) , 10.1002/JMV.21377
Wen-Yi Gao, Bing-Sen Zhou, David G Johns, Hiroaki Mitsuya, Yun Yen, Role of the M2 subunit of ribonucleotide reductase in regulation by hydroxyurea of the activity of the anti-HIV-1 agent 2',3'-dideoxyinosine Biochemical Pharmacology. ,vol. 56, pp. 105- 112 ,(1998) , 10.1016/S0006-2952(98)00127-0
Per-Olof Markgren, Wesley Schaal, Markku Hämäläinen, Anders Karlén, Anders Hallberg, Bertil Samuelsson, U. Helena Danielson, Relationships between structure and interaction kinetics for HIV-1 protease inhibitors. Journal of Medicinal Chemistry. ,vol. 45, pp. 5430- 5439 ,(2002) , 10.1021/JM0208370
G.L. Atkins, I.A. Nimmo, Current trends in the estimation of Michaelis-Menten parameters. Analytical Biochemistry. ,vol. 104, pp. 1- 9 ,(1980) , 10.1016/0003-2697(80)90268-7
Lin Shen, Susan Peterson, Ahmad R Sedaghat, Moira A McMahon, Marc Callender, Haili Zhang, Yan Zhou, Eleanor Pitt, Karen S Anderson, Edward P Acosta, Robert F Siliciano, Dose-response Curve Slope Sets Class-Specific Limits on Inhibitory Potential of Anti-HIV Drugs Nature Medicine. ,vol. 14, pp. 762- 766 ,(2008) , 10.1038/NM1777