n-3 polyunsaturated fatty acid supplementation reduces insulin resistance in hepatitis C virus infected patients: a randomised controlled trial.

摘要: Background Insulin resistance promotes liver disease progression and may be associated with a lower response rate in treated hepatitis C virus (HCV) infected patients. n-3 polyunsaturated fatty acid (PUFA) supplementation reduce insulin resistance. The present study aimed to evaluate the effect of PUFA on these patients. Methods In randomised, double-blind clinical trial, 154 patients were screened. After applying inclusion criteria, 52 [homeostasis model assessment index (HOMA-IR ≥2.5)] randomly divided into two groups: (n = 25/6000 mg day−1 fish oil) or control (n = 27/6000 mg day−1 soybean oil). Both groups supplemented for 12 weeks underwent monthly nutritional consultation. Biochemical tests performed at baseline after intervention. Statistical analysis was using Wilcoxon Mann–Whitney test comparisons paired data. package r, version 3.02 (The R Project Computing) used P < 0.05 (two-tailed) considered statistically significant. Results Comparisons between showed that more effective than reducing HOMA-IR (P = 0.015) serum (P = 0.016). The group not only significant reduction 3.8 (3.2–5.0) versus 2.4 (1.8–3.3) (P = 0.002); 17.1 (13.8–20.6) μIU mL−1 10.9 (8.6–14.6) μIU mL−1 (P = 0.001); glycated haemoglobin 5.4% (5.0–5.7%) 5.1% (4.8–5.6%) (P = 0.011), but also presented an increase interleukin-1 97.5 (0.0–199.8) pg mL−1 192.4 (102.2–266.8) pg mL−1 (P = 0.003) tumour necrosis factor 121.2 (0.0–171.3) pg mL−1 185.7 (98.0–246.9) pg mL−1 (P = 0.003). Conclusions n-3 reduces genotype 1 HCV