Regulation of superoxide stress in Pseudomonas putida KT2440 is different from the SoxR paradigm in Escherichia coli.

摘要: Abstract In Escherichia coli , the SoxR regulon orchestrates genes for defense against certain types of oxidative stress through SoxR-regulated synthesis SoxS transcription activator. The Pseudomonas putida genome did not reveal a clear soxS homolog. P. protein appears to be functional: its expression in an E. Δ soxR strain restored paraquat inducibility . Of nine candidate genes, which are known tested response superoxide or nitric oxide, fumC-1 sodA zwf-1 and particularly fpr encoding ferredoxin:NADP + reductase, were induced, all independent Disruption finR regulatory that is required paraquat-dependent resulted more sensitivity. However, -deletion had normal resistance superoxide-generating agent paraquat. data presented here show genetic responses differ markedly from those seen Salmonella role remains established.