Comparative pharmacology of selective serotonin re-uptake inhibitors (SSRIs)

摘要: Tricyclic antidepressants (TCAs) affect a series of neurotransmitter functions. The uptake noradrenaline (NA) and serotonin (5-HT) is inhibited to varying degree. Many the TCAs potently inhibit receptors. A newer preferentially increases 5-HT transmission by inhibiting uptake. Selective re-uptake inhibitors (SSRIs) are those which have high potency ratio 5-HT-uptake inhibition as compared NA-uptake inhibition, together with slight or no effect on other mechanisms, receptors, enzymes, etc. marketed SSRIs, citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline all fulfil above-mentioned criteria. Paroxetine most potent inhibitor, whereas citalopram selective. In general, rank order selectivity equal in vitro studies, biochemical vivo studies behavioural studies. Potency for do not coincide. contr...