Use of Monoclonal Antibodies to Detect Metastases of Solid Tumors in Lymph Nodes

摘要: Monoclonal antitumor antibodies provide the possibility of locating breast cancer metastases much smaller than those detectable by current non-invasive techniques. In case metastasis to axillary lymph nodes, a sensitive imaging technique might reduce need for surgery. It also detect small in internal mammary node chains, where surgical biopsy is not routinely performed. As an alternative more usual i.v. route administration monoclonal antibodies, we have been studying delivery via lymphatic vessels detection metastases. Using metastatic hepatocarcinoma guinea pigs, find that subcutaneous injection uptake capillaries leads specific localization antibody metastases, as indicated gamma camera imaging, double-label isotopic tracers, and autoradiography. When nodes are target, offers higher efficiency, faster localization, less systemic toxicity does route. addition, there may be cross-reaction with antigen expressed on normal cells.