Tuberculin skin test reactivity, anergy, and HIV infection in hospitalized patients

摘要: Purpose Detection of latent tuberculosis infection is an important step in the control because high-risk persons may be given preventive therapy. The value tuberculin skin testing individuals with human immunodeficiency virus (HIV) infection, however, limited by anergy. We evaluated prevalence test reactivity, anergy, and HIV a group hospitalized patients area where both are prevalent. Patients methods Three hundred fifty-one consecutively admitted to medical service large urban teaching hospital were enrolled study. All those no documented history positive on admission purified protein derivative (PPD) Mantoux test, anergy using multiple-puncture device. was offered all who did not have known performed when informed consent obtained. Results Forty-one (12%) had PPD. Of remaining 310 patients, 62 (20%) PPD response ≥10 mm induration. Fifty-two (15%) 351 positive. None HIV-infected Anergy found 63% 28% HIV-seronegative patients. Independent risk factors for included age >55, male sex, hypertension. current steroid use, cancer associated negative corticosteroid renal failure, pneumonia, cancer. new PPD-positive 30 (48%) candidates chemoprophylaxis. Additionally, (63%) 48 HIV-seropositive completed anergic might Almost eligible chemoprophylactic therapy would been detected if only at increased developing screened. Conclusions Tuberculosis common this service. Interpretation reactivity confounded high particularly A proportion tested Routine useful identifying benefit from prophylaxis help spread tuberculosis.