Impact of Method of Preparation of Amorphous Solid Dispersions on Mechanical Properties: Comparison of Coprecipitation and Spray Drying.

摘要: Abstract Usage of the amorphous phase compounds has become method choice to overcome oral bioavailability problems related poor solubility. Due unstable nature glasses, it is clear that preparation glass will have an impact on physical/chemical stability and in turn in vivo performance. The can also a profound mechanical properties phase. We explored solid dispersion using development compound, GDC-0810. Three methods were used generate dispersions (ASDs) 50% GDC-0810 with hydroxypropyl methylcellulose acetate succinate: (1) spray drying, (2) coprecipitation overhead mixing, (3) resonant acoustic mixing. All 3 found ASDs good mixing similar transition temperatures. Coprecipitated ASD powders (overhead mixing) demonstrated superior tabletability flow when compared drying powder. Careful manufacturing process be tune material make them more amenable for downstream operations like tableting. Acoustic been as scalable new through coprecipitation.