Circulating and hepatic Fas expression in HCV-induced chronic liver disease and hepatocellular carcinoma.

摘要: Apoptosis is central for control and elimination of viral infections. In chronic hepatitis C virus (HCV) infection, enhanced hepatocyte apoptosis upregulation the death-inducing ligands CD95/Fas occur. This study aimed to role serum soluble Fas hepatic expression as early predictors advancement disease. The current included 50 cases (CHC) (and negative B infection), 30 liver cirrhosis (LC) HCV, 20 hepatocellular carcinoma (HCC) HCV admitted Theodor Bilharz Research Institute, Giza, Egypt. Fifteen wedge biopsies, taken during laparoscopic cholecystectomy, were in normal controls. Assessment level (sFas) other laboratory investigations, including function tests, serologic markers hepatitis, alpha-fetoprotein (alpha-FP), determined all cases. Histopathologic immunohistochemistry using monoclonal antibody CD95 also done. sFas was significantly increased CHC, LC, HCC compared with controls (P < .01). increase higher than that CHC However, positive antigen LC no significant difference; meanwhile, it lower .01) CHC. conclusion, circulating infection illustrate mechanism injury caused by death receptors throughout multistep process fibrosis/carcinogenesis. Not only degree fibrosis, but protein, are correlated incidence HCC.