Impact of DNA mismatch repair system alterations on human fertility and related treatments
作者： Min-hao Hu , Shu-yuan Liu , Ning Wang , Yan Wu , Fan Jin
关键词:
摘要: DNA mismatch repair (MMR) is one of the biological pathways, which plays a critical role in homeostasis, primarily by repairing base-pair mismatches and insertion/deletion loops that occur during replication. MMR also takes part other metabolic pathways regulates cell cycle arrest. Defects are associated with genomic instability, predisposition to certain types cancers resistance therapeutic drugs. Moreover, genetic epigenetic alterations system demonstrate significant relationship human fertility related treatments, helps us understand etiology susceptibility infertility. Alterations may influence health offspring conceived assisted reproductive technology humans. However, further studies needed explore specific mechanisms affect This review addresses physiological associations between potential effects on next generation.
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T V Serebrovskaya, Z A Serebrovska, R L Pyle, M L Di Pietro, Transmission of male infertility and intracytoplasmic sperm injection (mini-review). Fiziolohichnyĭ zhurnal. ,vol. 52, pp. 110- 118 ,(2006)
Jeong-Yeol Park, Seok Ju Seong, Tae-Jin Kim, Jae Weon Kim, Seok Mo Kim, Duk-Soo Bae, Joo-Hyun Nam, Pregnancy outcomes after fertility-sparing management in young women with early endometrial cancer. Obstetrics & Gynecology. ,vol. 121, pp. 136- 142 ,(2013) , 10.1097/AOG.0B013E31827A0643
Ana D. Martins, Ana C. Moreira, Rosália Sá, Mariana P. Monteiro, Mário Sousa, Rui A. Carvalho, Branca M. Silva, Pedro F. Oliveira, Marco G. Alves, Leptin modulates human Sertoli cells acetate production and glycolytic profile: a novel mechanism of obesity-induced male infertility? Biochimica et Biophysica Acta. ,vol. 1852, pp. 1824- 1832 ,(2015) , 10.1016/J.BBADIS.2015.06.005
Steven M. Lipkin, Victoria Wang, Russell Jacoby, Sharmila Banerjee-Basu, Andreas D. Baxevanis, Henry T. Lynch, Rosemary M. Elliott, Francis S. Collins, MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability. Nature Genetics. ,vol. 24, pp. 27- 35 ,(2000) , 10.1038/71643
Marco G. Alves, Pedro F. Oliveira, Ana D. Martins, Ana C. Moreira, C. Yan Cheng, The Warburg Effect Revisited—Lesson from the Sertoli Cell Medicinal Research Reviews. ,vol. 35, pp. 126- 151 ,(2015) , 10.1002/MED.21325
Winfried Edelmann, Paula E. Cohen, Burkhard Kneitz, Nena Winand, Marie Lia, Joerg Heyer, Richard Kolodner, Jeffrey W. Pollard, Raju Kucherlapati, Mammalian MutS homologue 5 is required for chromosome pairing in meiosis Nature Genetics. ,vol. 21, pp. 123- 127 ,(1999) , 10.1038/5075
Tuija Hienonen, Päivi Laiho, Reijo Salovaara, Jukka-Pekka Mecklin, Heikki Järvinen, Pertti Sistonen, Päivi Peltomäki, Rainer Lehtonen, Nina N. Nupponen, Virpi Launonen, Auli Karhu, Lauri A. Aaltonen, Little evidence for involvement of MLH3 in colorectal cancer predisposition. International Journal of Cancer. ,vol. 106, pp. 292- 296 ,(2003) , 10.1002/IJC.11218
Ying Wu, Maran J.W. Berends, Rolf H. Sijmons, Rob G.J. Mensink, Edwin Verlind, Krista A. Kooi, Tineke van der Sluis, Claudia Kempinga, Ate G.J. van der Zee, Harry Hollema, Charles H.C.M. Buys, Jan H. Kleibeuker, Robert M.W. Hofstra, A role for MLH3 in hereditary nonpolyposis colorectal cancer Nature Genetics. ,vol. 29, pp. 137- 138 ,(2001) , 10.1038/NG1001-137
Sezgin Gunes, Maha Al-Sadaan, Ashok Agarwal, Spermatogenesis, DNA damage and DNA repair mechanisms in male infertility Reproductive Biomedicine Online. ,vol. 31, pp. 309- 319 ,(2015) , 10.1016/J.RBMO.2015.06.010
A. Kochanski, T. A. Merritt, J. Gadzinowski, A. Jopek, The impact of assisted reproductive technologies on the genome and epigenome of the newborn. Journal of neonatal-perinatal medicine. ,vol. 6, pp. 101- 108 ,(2013) , 10.3233/NPM-1366812