作者: Ye Luo , Jonathan P. Davis , Svetlana B. Tikunova , Lawrence B. Smillie , Jack A. Rall
DOI: 10.1007/978-1-4419-9029-7_51
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摘要: Muscle relaxation occurs when Ca2+, sequestrated by the sarcoplasmic reticulum (SR) Ca2+ pump, dissociates from troponin (Tn) to deactivate thin filaments leading cross-bridge detachment and force decay. It is well established that rate of sequestration SR can control kinetics.1 The aim present investigation determine relative contribution dissociation TnC induced rapid Ca2+. Three possibilities be envisioned. First, may much faster than detachment. In this case, only kinetics would affect rate. Second, similar If relationship were true, both Third, slower possibility then