Increased Levels of Circulating Islet Amyloid Polypeptide in Patients with Chronic Renal Failure Have No Effect on Insulin Secretion
作者： B Ludvik , M Clodi , A Kautzky-Willer , M Schuller , H Graf
DOI: 10.1172/JCI117558
关键词:
摘要: To elucidate the metabolism of islet amyloid polypeptide (IAPP) with respect to a possible renal elimination we investigated IAPP levels in 20 lean, nondiabetic patients failure maintained on chronic hemodialysis (HD) and healthy controls. The basal were significantly higher uremic than controls (15.1 +/- 3.2 vs. 0.2 pM, P < 0.001) suggesting excretion IAPP. investigate impact chronically elevated endogenous insulin secretion sensitivity, frequently sampled intravenous glucose tolerance test (FSIGT) was performed subset age-matched (C) obese normal (NGT) impaired (IGT). Insulin sensitivity index (SI) 8.7 1.5 C (P 0.05 NGT, 0.01 IGT), 5.4 0.9 HD 3.1 1.0 2.0 0.5 IGT. First phase increased compared those several control groups. results this study therefore indicate route Increased circulating over long period time do not lead decrease release cause resistance commonly seen obesity diabetes. are likely be pathogenetic factor development non-insulin-dependent diabetes mellitus (NIDDM).
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