Human Amylin: From Pathology to Physiology and Pharmacology

摘要: The histopathological hallmark of type 2 diabetes is islet amyloid implicated in the developing treatment options. major component human 37 amino acid peptide known as amylin or polypeptide (IAPP). Amylin an important hormone that co-localized, copackaged, and co-secreted with insulin from β cells. Physiologically, regulates glucose homeostasis by inhibiting glucagon secretion. Furthermore, modulates satiety inhibits gastric emptying via central nervous system. Normally, IAPP soluble natively unfolded its monomeric state. Pathologically, has a propensity to form oligomers aggregate. show misfolded α-helix conformation can further convert themselves β-sheet-rich fibrils deposits. pathological findings physiological functions have led introduction pramlintide, analog, for diabetes. history amylin's discovery representative example how finding translate into exploration lead pharmacological intervention. Understanding importance transitioning pathology physiology pharmacology provide novel insight mellitus Alzheimer's disease.