Prevalence of anal HPV infection in solid‐organ transplant patients prior to immunosuppression

摘要: Patients that undergo organ transplantation have a high risk of developing various malignancies, depending on the duration and magnitude immunosuppressive therapy. Among others, 10-fold increased relative has been reported for development anal cancer. There is strong association between persistent infection with high-risk mucosal types human papillomavirus (HPV) anogenital neoplasia. In this study we analysed prevalence HPV in transplant patients before starting university unit, (n=60, 40 male, 20 female) were undergoing solid-organ (kidney, liver) first time routinely screened infection. Anal swabs obtained within 24 h after presence mucosal-type DNA by liquid DNA/RNA hybridization [hybrid capture (HC) 2 test]. Overall, some type was detected 14/60 (23.3%) patients; 9/60 (15%) positive 8/60 (13.4%) low-risk HPV, 3/60 (5%) both types. Prevalence tended to be higher receiving liver transplants than those kidney (29.4% vs. 20.9%), but difference did not reach statistical significance. our series previous therapy started found epidemiological studies or control group. particular, there rate oncogenic These findings important implications screening surveillance policies patient group at neoplasias, including