Involvement of ROS/ASMase/JNK signalling pathway in inhibiting UVA-induced apoptosis of HaCaT cells by polypeptide from Chlamys farreri
作者： Yan-Xia Xing , Ping Li , Yuan-Xin Miao , Wei Du , Chun-Bo Wang
DOI: 10.1080/10715760701762415
关键词:
摘要: Polypeptide from Chlamys farreri (PCF), a novel marine active material isolated gonochoric Chinese scallop C. farreri, has potential antioxidant activity and protective effect against ultraviolet (UV) irradiation. The aim was to investigate whether PCF protects HaCaT cells apoptosis induced by UVA explore related molecular mechanisms. results showed that significantly prevented UVA-induced of cells. not only strongly reduced the intracellular reactive oxygen species (ROS) production, but also diminished expression acid sphingomyelinase (ASMase) phosphorylated JNK in radiated dose-dependent manner. Pre-treatment with ROS scavenger NAC, ASMase inhibitor Desipramine or SP600125 found effectively prohibit markedly blocked phosphorylation JNK. So it is concluded obviously effects may attribute decreas...
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