Delivery of Nucleic Acids and Gene Delivery
作者： H. Akita , H. Hatakeyama , I.A. Khalil , Y. Yamada , H. Harashima
DOI: 10.1016/B978-0-08-055294-1.00150-1
关键词:
摘要: Efficient nonviral gene delivery systems are urgently needed to replace viral vectors for successful nucleic acid cells and gene-based therapies. Nonviral have several advantages over particularly from the viewpoints of safety commercial production. However, low efficiency transfer mediated by remains an obstacle. In this chapter, we discuss some general strategies related safe efficient functional acids a site action. The mechanisms action types summarized, mechanism RNA interference is also discussed. Major carrier systems, such as cationic liposomes polymers briefly To achieve efficiency, controlling pharmacokinetics these selective targeting at tissue level important issue. Strategies escaping immune recognition reaching target tissues introduced. After entering cell, controlled intracellular trafficking required delivery, cutting-edge technology that clearly needs be better developed in twenty-first century. Finally, current status vivo discussed, along with obstacles must overcome future enable clinically attractive technologies.
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