CD4+ T-cell count monitoring does not accurately identify HIV-infected adults with virologic failure receiving antiretroviral therapy.

摘要: BACKGROUND CD4 T-lymphocyte (CD4) counts are widely used to monitor response antiretroviral therapy (ART) in resource-limited settings. However, the utility of such monitoring terms predicting virologic has been little studied. METHODS We studied participants aged 18 years and older who initiated ART Tororo, Uganda. counts, percentages, viral load (VL) were examined at 6-monthly intervals. Various definitions immunologic failure identify individuals with VLs>or=50, >or=500, >or=1000, or >or=5000 copies per milliliter 6, 12, months after treatment initiation. RESULTS One thousand sixty-three ART-naive persons ART. The proportion ranged between 1.5% 16.4% for each time point. no increase count from baseline did not differ those suppressed unsuppressed VLs 18, 24 No cell 6 had a sensitivity 0.04 [95% confidence interval (CI) 0.00 0.10] positive predictive value 0.03 (95% CI 0.09) identifying VL>or=500 months. best measure identified was an absolute or=500 which 0.13 0.01 0.21) 0.29 0.10 0.44). CONCLUSIONS does accurately among patients taking